High-dose loratadine exposure in a six-year-old child

Cobb, D.B.; Watson, W.A.; Fernández, M.C.

Veterinary and Human Toxicology 43(3): 163-164


ISSN/ISBN: 0145-6296
PMID: 11383659
Document Number: 1653
Loratadine is a long-acting antihistamine indicated for the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria in patients 6 years of age and older. The literature contains little information on high-dose loratadine exposures; as a consequence, poison centers are unsure of the loratadine dose that can be managed with observation and the dose that requires treatment. We report an intentional ingestion of 300 mg loratadine by a 6-y-old child that resulted in minor elevation of blood pressure and heart rate when managed with supportive care only. Further studies and case series are needed before a minimum toxic dose can be established.

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High-dose loratadine exposure in a six-year-old child