Top Abstract Purchase Related
Home
>
Node
>
Subnode

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes

Law, S.K.; Lichtenberg, N.A.; Holcombe, F.H.; Levine, R.P.

Journal of Immunology 125(2): 634-639

1980

ISSN/ISBN: 0022-1767
PMID: 7391573
Document Number: 164414
We have shown that the labile binding site of C3b interacts covalently with receptive surfaces. We report here an analogous study of the interaction between the labile binding sites of the closely related complement proteins, C4 and C5, with sheep erythrocyte membranes. We find that i) C4b binds covalently to cell surface components; ii) the bond between C4b and receptive molecules is hydroxylamine sensitive; iii) the alpha-polypeptide of C4b binds to receptive molecules; and iv) C5b does not interact covalently with cell surfaces.

Document emailed within 1 workday
Secure & encrypted payments

Li, Y.P.; Mold, C.; Du Clos, T.W. 1994: Sublytic complement attack exposes C-reactive protein binding sites on cell membranes Journal of Immunology 152(6): 2995-3005
von Zabern, I.; Bloom, E.L.; Chu, V.; Gigli, I. 1982: The fourth component of human complement treated with amines or chaotropes or frozen-thawed (C4b-like C4): interaction with C4 binding protein and cleavage by C3b/C4b inactivator Journal of Immunology 128(3): 1433-1438
Dambinova, S.A.; Lekomtseva, T.M.; Margulis, M.N.; Ogurtsov, R.P. 1987: Molecular organization of glutamate-sensitive chemo-stimulated nerve cell membranes. Interaction of monoclonal antibodies with glutamate-binding membrane proteins in the rat brain, human neuroblastoma and molluscan neurons Biokhimiia 52(9): 1523-1530
Liu, Z.Y.; Sanders, M.E.; Hu, V.W. 1989: Effect of complement on the lateral mobility of erythrocyte membrane proteins. Evidence for terminal complex interaction with cytoskeletal components Journal of Immunology 142(7): 2370-2376
Linss, W.; Geyer, G.; Richter, H.; Helmke, U. 1972: Quantitative studies on distribution of acidic binding sites on human erythrocyte ghosts Acta Biologica et Medica Germanica 28(1): 7-12
Edwards, J.E.; Gaither, T.A.; O'Shea, J.J.; Rotrosen, D.; Lawley, T.J.; Wright, S.A.; Frank, M.M.; Green, I. 1986: Expression of specific binding sites on Candida with functional and antigenic characteristics of human complement receptors Journal of Immunology 137(11): 3577-3583
McCann, D.J.; Su, T.P. 1991: Solubilization and characterization of haloperidol-sensitive (+)-[3H]SKF-10,047 binding sites (sigma sites) from rat liver membranes Journal of Pharmacology and Experimental Therapeutics 257(2): 547-554
Gorga, F.; Ianniello, R.; Petrillo, G.; Provenzi, E.; Tufano, M.A. 1992: The presence in human spermatozoa of sites binding some proteins of the outer membrane of Escherichia coli Microbiologica 15(2): 187-190
Kozlov, L.V.; Sizoĭ, M.N.; Zinchenko, A.A.; Levkovskiĭ, A.V. 1986: Inhibition of the binding and activation of the first component of human complement. The effect of synthetic peptides, immunoglobulin fragments and various proteins Biokhimiia 51(5): 707-718
Melamed, J.; Arnaout, M.A.; Colten, H.R. 1982: Complement (C3b) interaction with the human granulocyte receptor: correlation of binding of fluid-phase radiolabeled ligand with histaminase release Journal of Immunology 128(5): 2313-2318
Anderson, J.M.; Tyler, J.M. 1979: Proteolytic fragmentation of spectrin:effect of removal of terminal phosphopeptides on spectrin binding to human erythrocyte membranes Progress in Clinical and Biological Research 30(8): 531-534
Chojnowski, W.; Gralewicz, J. 1976: Quantitative and qualitative aspects of the interaction of antibiotics with proteins. I. Binding of rifampicin and novobiocin to human blood albumin Acta Poloniae Pharmaceutica 33(2): 235-238
Alemà, S.; Bianconi, A.; Castellani, L.; Fasella, P. 1982: X-ray absorption spectroscopy (EXAFS and XANES) a structural tool for calcium binding proteins: effect of Mg2+ on Ca2+ binding sites of troponin-C Progress in Clinical and Biological Research 102 Pt C: 47-57
Tedesco, F.; Narchi, G.; Radillo, O.; Meri, S.; Ferrone, S.; Betterle, C. 1993: Susceptibility of human trophoblast to killing by human complement and the role of the complement regulatory proteins Journal of Immunology 151(3): 1562-1570
Tardif, G.; Reboul, P.; Dupuis, M.; Geng, C.; Duval, N.; Pelletier, J.P.; Martel-Pelletier, J. 2001: Transforming growth factor-beta induced collagenase-3 production in human osteoarthritic chondrocytes is triggered by Smad proteins: cooperation between activator protein-1 and PEA-3 binding sites Journal of Rheumatology 28(7): 1631-1639
Nevinskiĭ, G.A.; Potapova, I.A.; Tarusova, N.B.; Khalabuda, O.V.; Khomov, V.V. 1990: Interaction of dNTP-binding sites of human DNA polymerase alpha and the Klenow fragment of Escherichia coli DNA polymerase i with nucleotides, pyrophosphate and their analogs Molekuliarnaia Biologiia 24(1): 104-116
Sharma, I.N.; Gupta, G.S.; Dubey, D.P. 1978: Calci-m-45 binding with erythrocyte membranes during dyserythropoiesis Indian Journal of Biochemistry and Biophysics 15(2): 143-145
Lignon, M.F.; Bernad, N.; Martinez, J. 1991: Pharmacological characterization of type B cholecystokinin binding sites on the human JURKAT T lymphocyte cell line Molecular Pharmacology 39(5): 615-620
Gu, X.H.; Ou, R.C.; Casley, D.J.; Daly, M.J.; Nayler, W.G. 1992: Effect of age on endothelin-1 binding sites in rat cardiac ventricular membranes Journal of Cardiovascular Pharmacology 19(5): 764-769
Dubois, M.; Picq, M.; Prigent, A.F.; Némoz, G.; Pacheco, H. 1988: Characterization of penta-O-ethylquercetin binding sites in rat brain membranes Progress in Clinical and Biological Research 280: 151-155