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Widespread Skin Necrosis Secondary to Gemcitabine Therapy

Zito, P.M.; Gonzalez, A.M.; Fox, J.D.; Cronin, M.; Mackrides, N.; Kirsner, R.S.; Nichols, A.J.

Journal of Drugs in Dermatology Jdd 17(5): 582-585

2018

ISSN/ISBN: 1545-9616
PMID: 29742194
Document Number: 16380
Gemcitabine, a pyrimidine nucleoside analogue, is an oncologic agent used in the treatment of cutaneous T-cell lymphoma (CTCL). Common dermatologic reactions associated with gemcitabine include alopecia, mild skin rash, and mucositis but skin necrosis is exceptional. Herein we present an unusual case of widespread skin necrosis mimicking toxic epidermal necrolysis in a 45-year-old woman receiving gemcitabine therapy for stage IIIA cutaneous T-cell lymphoma. This is the first reported case of a TEN-like reaction subsequent to gemcitabine treatment.

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Widespread Skin Necrosis Secondary to Gemcitabine Therapy

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