Turnover of chromatin proteins in rat liver during induction of RNA synthesis by electrostimulation of the hypothalamus
Tiulenev, V.I.; Kapralov, A.A.; Masiuk, A.I.
Biokhimiia 45(9): 1669-1674
1980
ISSN/ISBN: 0320-9725 PMID: 6166330 Document Number: 163225
It has been shown that the induction of D-RNA synthesis in rat liver nuclei by electrostimulation of hypothalamus is accompanied by a decrease in chromatin protein synthesis and an increase in phosphorylation and acetylation of chromatin proteins. The decrease of the histone synthesis is mainly due to the decrease of [14C]lysine and [14C]alanine incorporation into histones H1 and H4. The relationship between H1, H2b-H3, H2a and H4 histone fractions remains unchanged. Electrostimulation of hypothalamus increases acetylation of H2a and H4 histone fractions and phosphorylation of all histones with the exception of histone H1.