Effects of glibenclamide on normal rabbits: a biochemical study
Annamala, P.T.; Augusti, K.T.
Indian Journal of Experimental Biology 18(8): 847-849
1980
ISSN/ISBN: 0019-5189 PMID: 6780453 Document Number: 162870
Normal rabbits on treatment with glibenclamide, the most potent hypoglycemic agent, showed improvement in glucose tolerance, increase in body wt, serum and liver lipids, liver free amino acids and serum urea, and decrease in blood sugar, liver proteins and glycogen. Glibenclamide has an antilipolytic effect both in vivo and in vitro. The possible mechanism of action of the drug is discussed.
Document emailed within 1 workday
Related Documents
Kumar, V.; Gulatia, R.K.; Ahuja, M.M. 1971: A clinical and biochemical study of 12 cases of acromegaly with special reference to plasma I.R.I. and FFA on glibenclamide administration Journal of the Association of Physicians of India 19(9): 623-627Kamstrup, O.; Hugod, C. 1979: Exposure of rabbits to 50 ppm carbonyl sulfide. A biochemical and histomorphological study International Archives of Occupational and Environmental Health 44(2): 109-116
Meyers, O.L.; Hickman, R.; Keraan, M.; Engelbrecht, G.H.; Webber, B.L.; Terblanche, J. 1975: Acute biochemical and histological effects of portacaval shunt in the normal rat South African Medical Journal 49(26): 1048-1050
Niyo, K.A.; Richard, J.L.; Niyo, Y.; Tiffany, L.H. 1988: Effects of T-2 mycotoxin ingestion on phagocytosis of Aspergillus fumigatus conidia by rabbit alveolar macrophages and on hematologic, serum biochemical, and pathologic changes in rabbits American Journal of Veterinary Research 49(10): 1766-1773
Qiu, H.Y.; Wei, T.X.; Zhang, Y.R.; Yan, X.F.; Wei, J.H. 1993: Effects of ranitidine on ventricular refractory period and fibrillation threshold of normal and ischemic ventricle in rabbits Zhongguo Yao Li Xue Bao 14(3): 260-262
Litvinenko, L.T.; Gulii, M.F.; Chumachenko, I.V.; Pisarevich, O.V. 1971: Comparative study of alpha-glycerophosphate dehydrogenase in normal and fasting rabbits Ukrains'kyi Biokhimichnyi Zhurnal 43(4): 436-440
Neumann, H.; Wilson, K.J.; Hauck-Granoth, R.; Haran-Ghera, N. 1971: A comparative biochemical study of alkaline phosphatases in normal and leukemic mice Cancer Research 31(11): 1695-1701
Hoover, E.L.; Ross, M.J.; Fani, K.; Adams, C.Z.; Debons, A.F. 1991: The effects of dimethyl sulfoxide on aortic prostacyclin production and serum thromboxane and plasma fibrinogen levels in rabbits fed a normal versus a cholesterol-enriched diet Surgery 109(1): 69-75
Teranishi, C. 1988: A study on the effects of different keratectomies for astigmatism in rabbits' eyes Hokkaido Journal of Medical Science 63(1): 56-71
Henon, M.; Delaunay, A. 1970: Experimental diabetes and anti-infectious defense of the organism. II. Modifications of bactericidal power exerted by serums of diabetic rabbits and of polynuclears of normal rabbits brought into contact with these serums Annales de l'Institut Pasteur 118(5): 646-656
Zarbo, R.J.; Bacchi, C.E.; Gown, A.M. 1991: Muscle-specific protein expression in normal salivary glands and pleomorphic adenomas: an immunocytochemical study with biochemical confirmation Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology Inc 4(5): 621-626
Adaramoye, O.; Akanni, O.; Adesanoye, O.; Labo-Popoola, O.; Olaremi, O. 2012: Evaluation of toxic effects of metformin hydrochloride and glibenclamide on some organs of male rats Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria 27(2): 137-144
Cavero, I.; Mondot, S.; Mestre, M. 1989: Vasorelaxant effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels Journal of Pharmacology and Experimental Therapeutics 248(3): 1261-1268
Roche, M. 1970: Comparative study of the central effects of psychodysleptics in rabbits and cats Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 164(4): 864-869
Guy, A.W.; Harris, C.; Kramer, P.O.; Emery, A.F. 1976: Study of the effects of chronic low level microwave radiation on rabbits Journal of Microwave Power 11(2): 134-135
Weinges, K.F. 1970: Comparative studies of the effects of glibenclamide and tolbutamide on insulin release from isolated rat islets in vitro Postgraduate Medical Journal 1970(Suppl): 32-35
León Castro, J.; Yáñez Polo, M.A.; Sauret Valet, J.; De la Lama, J. 1971: Diabetes mellitus in adults and glibenclamide. Effects on lipid, protein, and carbohydrate metabolism in diabetics Revista Clinica Espanola 120(2): 131-142
Glatzel, W.; Grünes, J.W.; Tietze, K. 1970: Carbon tetrachloride in its effects on peripheral nerves (experimental study on rabbits) Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 25(13): 600-601
Khosla, P.; Bhanwra, S.; Singh, J.; Seth, S.; Srivastava, R.K. 2000: A study of hypoglycaemic effects of Azadirachta indica (Neem) in normaland alloxan diabetic rabbits Indian Journal of Physiology and Pharmacology 44(1): 69-74
Dupuis, P.R.; Uhthoff, H.K. 1972: In vivo study of the effects of a synthetic steroid, betamethasone (16B methyl-9X fluoroprednisolone) on the calcaneal tendon in rabbits L'Union Medicale du Canada 101(9): 1763-1767