A molecular abnormality of the erythrocyte membrane in beta-thalassemia
Morle, F.; Morle, L.; Aguercif, M.; Alloisio, N.; Delaunay, J.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 174(4): 598-604
1980
ISSN/ISBN: 0037-9026 PMID: 6254622 Document Number: 162768
We present a new abnormality of the red cell membrane observed in the course of a study on beta-thalassemia. In a child suffering from a beta 0-thalassemia major, the neutral membrane bound phosphatase, instead of having Michaelis-Menten kinetics, displayed a biphasic kinetics consistent with inhibition by substrate excess. This abnormality is discussed along with other erythrocyte membrane alterations that are known to occur in beta-thalassemia.
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