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Evidence for the influence of the initial complement components on the assembly and activity of the membrane attack complex

Boyle, M.D.; Ohanian, S.H.

Journal of Immunology 124(6): 2824-2827

1980

ISSN/ISBN: 0022-1767
PMID: 7373051
Document Number: 161540
The failure of functionally purified C5gp to bind and activate C5gp, but was related to the failure of EAC1-3hu5gp6hu to efficiently bind C7hu in a form that would lead to lysis when HuC8 and HuC9 were added. This failure was not observed with EAC1-3gp5gp6hu or EAC1-3hu5hu6hu, which could be lysed with any combination of human or guinea pig C7 through C9. The implications of these findings on the control of the lytic C attack mechanism by the initial components in the C cascade are discussed.

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