Effect of experimentally induced diabetes on swine vascular prostacyclin (PGI2) synthesis
Silberbauer, K.; Clopath, P.; Sinzinger, H.; Schernthaner, G.
Artery 8(1): 30-36
1980
ISSN/ISBN: 0098-6127 PMID: 6448594 Document Number: 161029
Repeated administration of streptozotocin to Göttingen miniature swine led to the development of a mild form of diabetes. The amount of PGI2 generated by the vessels (abdominal aorta, thoracic aorta, pulmonary artery), as estimated by reference to inhibition of ADP-induced platelet aggregation, was lower in the treated animals than in the controls. The decrease in the synthesis of PGI2 may contribute to the prethrombotic state in diabetes mellitus.
Document emailed within 1 workday
Related Documents
Jeremy, J.Y.; Gill, J.; DuBourg, A.; Pelat, P.; Mikhailidis, D.P. 1993: Effect of buflomedil on in vitro prostacyclin and endothelin synthesis by vascular (rat and human) and penile (rat) tissue and calcium uptake by isolated human platelets International Journal of Impotence Research 5(3): 139-147Marotta, F.; Harada, M.; Dallah, E.D.; Yadav, H.; Solimene, U.; Di Lembo, S.; Minelli, E.; Jain, S.; Chui, D.H. 2010: Protective effect of a poly-phytocompound on early stage nephropathy secondary to experimentally-induced diabetes Journal of Biological Regulators and Homeostatic Agents 24(1): 41-49
Kumarappan, C.T.; Thilagam, E.; Vijayakumar, M.; Mandal, S.C. 2012: Modulatory effect of polyphenolic extracts of Ichnocarpus frutescens on oxidative stress in rats with experimentally induced diabetes Indian Journal of Medical Research 136(5): 815-821
Hechtman, D.H.; Kroll, M.H.; Gimbrone, M.A.; Schafer, A.I. 1991: Platelet interaction with vascular smooth muscle in synthesis of prostacyclin American Journal of Physiology 260(5 Pt 2): H1544-H1551
Sinzinger, H.; Firbas, W.; Cromwell, M. 1983: Radiation vasculopathy--caused by a change in vascular prostacyclin synthesis? Wiener Klinische Wochenschrift 95(21): 761-765
Bertschinger, H.U.; Keller, H.; Lohrer, A.; Wegmann, W. 1972: Temporal course of experimentally induced enzootic pneumonia in SPF-swine Schweizer Archiv für Tierheilkunde 114(2): 107-118
Thoen, C.O.; Johnson, D.W.; Himes, E.M.; Menke, S.B.; Muscoplat, C.C. 1976: Experimentally induced Mycobacterium avium serotype 8 infection in swine American Journal of Veterinary Research 37(2): 177-181
Silberbauer, K.; Schernthaner, G.; Sinzinger, H.; Piza-Katzer, H.; Winter, M. 1979: Decreased vascular prostacyclin in juvenile-onset diabetes New England Journal of Medicine 300(7): 366-367
Satake, K.; Lee, J.-D.; Shimizu, H.; Uzui, H.; Mitsuke, Y.; Yue, H.; Ueda, T. 2004: Effects of magnesium on prostacyclin synthesis and intracellular free calcium concentration in vascular cells Magnesium Research 17(1): 20-27
Yancey, R.J.; Evans, R.A.; Kratzer, D.D.; Paulissen, J.B.; Carmer, S.G. 1990: Efficacy of ceftiofur hydrochloride for treatment of experimentally induced colibacillosis in neonatal swine American Journal of Veterinary Research 51(3): 349-353
Chijimatsu, Y. 1983: A study of prostaglandin F2 alpha metabolism in experimentally induced pulmonary vascular bed diminution and oleic-acid induced lung injury in dogs Nihon Kyobu Shikkan Gakkai Zasshi 21(12): 1182-1186
Turner, T.T.; Caplis, L.A.; Brown, K.J. 1996: Vascular anatomy of experimentally induced left varicocele in the rat Laboratory Animal Science 46(2): 206-210
Aliev, M.A.; Lemeshenko, V.A.; Bekbolotova, A.K. 1997: Effect of transient cerebral ischemia on the synthesis of prostacyclin in dogs with arterial hypertension Biulleten' Eksperimental'noi Biologii i Meditsiny 124(9): 280-282
Jeynes, B.J. 1986: An assessment of the extent and distribution of experimentally induced cerebral atheroembolic vascular occlusions and infarcts Artery 14(1): 35-42
Dyerberg, J.; Jørgensen, K.A. 1980: The effect of arachidonic- and eicosapentaenoic acid on the synthesis of prostacyclin-like material in human umbilical vasculature Artery 8(1): 12-17
Bertelli, A.; Giovannini, L.; Galmozzi, G.; Bertelli, A.A. 1993: Protective role of propionyl carnitine in vascular disorders experimentally induced by endothelin (ET-1) serotonin and K-carrageenin Drugs under Experimental and Clinical Research 19(1): 7-11
Mehta, J.; Mehta, P.; Lawson, D.L.; Ostrowski, N.; Brigmon, L. 1985: Influence of selective thromboxane synthetase blocker CGS-13080 on thromboxane and prostacyclin biosynthesis in whole blood: evidence for synthesis of prostacyclin by leukocytes from platelet-derived endoperoxides Journal of Laboratory and Clinical Medicine 106(3): 246-252
Bastida, E.; Almirall, L.; Ordinas, A.; Buchanan, M.R.; Orr, F.W.; Bertomeu, M.C.; Haas, T.A. 1991: Effects of endothelial cell treatment on 13-HODE and prostacyclin synthesis and its correlation with tumor cell-vascular endothelial cell adhesion Invasion and Metastasis 11(5): 273-280
Williamson, J.R.; Arrigoni-Martelli, E. 1992: The roles of glucose-induced metabolic hypoxia and imbalances in carnitine metabolism in mediating diabetes-induced vascular dysfunction International Journal of Clinical Pharmacology Research 12(5-6): 247-252
Belgrade, M.J.; Solomon, L.M.; Lichter, E.A. 1984: Effect of acupuncture on experimentally induced itch Acta Dermato-Venereologica 64(2): 129-133