Warfarin-induced skin necrosis mimicking calciphylaxis: a case report and review of the literature
Chacon, G.; Nguyen, T.; Khan, A.; Sinha, A.; Maddirala, S.
Journal of Drugs in Dermatology Jdd 9(7): 859-863
2010
ISSN/ISBN: 1545-9616 PMID: 20677545 Document Number: 16068
Warfarin-induced skin necrosis (WISN) and calciphylaxis share similar early clinical findings and can both lead to significant morbidity and mortality. The authors reviewed the literature on both conditions and describe a case of extensive skin necrosis in a patient with end-stage renal disease who was initially suspected to have calciphylaxis. Further investigation supported a diagnosis of WISN. The pathogenesis, clinical manifestations and treatment of WISN and calciphylaxis are discussed, with emphasis on a diagnostic approach for early recognition.
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