Activity of small intestine alkaline phosphatase in the feces in chronic intestinal diseases
Lehmann, F.G.; Cramer, P.; Hillert, U.
Zeitschrift für Gastroenterologie 18(4): 208-215
1980
ISSN/ISBN: 0044-2771 PMID: 7424074 Document Number: 160673
In comparison to normal controls (n = 71) the activity of intestinal alkaline phosphatase in feces is reduced in chronic bowel disease using an immunoprecipitation method: patients with Crohns disease (n = 40) or inactive ulcerative colitis (n = 29) demonstrate small changes of fecal intestinal alkaline phosphate activity in comparison to normal controls. Intestinal alkaline phosphatase is reduced in patients with active ulcerative colitis (n = 11) to 50%, in patients with uraemic enteropathy (n = 18) to 30% and in patients with coeliac disease (n = 14) to 20% of the activity observed in normal controls. During cytostatic treatment of malignant tumors, fecal intestinal alkaline phosphatase activity increases as a sign of toxic damage of the intestinal mucosa.