Mechanism of early damage to the cardiovascular system by cardiotoxic serum
Sirotina, M.F.
Biulleten' Eksperimental'noi Biologii i Meditsiny 89(3): 360-362
1980
ISSN/ISBN: 0365-9615 PMID: 7388147 Document Number: 159762
Capillaries, small heart vessels, and internal organs (lungs, liver, kidneys, spleen, skeletal muscles, etc.) were subjected to morphofunctional study in experiments on 50 dogs with acute cytotoxic injury provoked by administering 0.5-1.5 ml of anticardial serum (ACS) into the coronary vascular bed. It was shown that ACS administration is attended by an extended reaction of the microvascular bed of the entire organism, involving disturbed capillary permeability by macromolecular compounds and appreciable changes in the morphologic structure of microvessels, with the greatest intensity seen in the left ventricular myocardium.