Interstitial pneumonitis induced by ingestion of palmitoyl glycerol
Schnitzer-Polokoff, R.; Kanich, R.E.; Tove, S.B.
Journal of Nutrition 110(12): 2396-2408
1980
ISSN/ISBN: 0022-3166 PMID: 7441370 Document Number: 159490
Weanling male mice given rac-1(3)-palmitoyl glycerol at 30 mmol/100 g diet, or more, developed within a few days, a severe pulmonary inflammation characterized by profound infiltration of the interstitium by macrophages and a few polymorphonuclear leucocytes. That resulted in severe vascular stasis, alveolar collapse and death. Adult mice and weanling rats also showed the syndrome, but only with larger amounts of palmitoyl glycerol. Neither the position of palmitate on the glycerol nor the amount of myoinositol in the diet affected the toxicity of palmitoyl glycerol. Supplementation of the diet with small amounts of linoleate or oleate prevented the toxicity, although oleate was less effective than linoleate. There were no differences between mice given linoleate and those which were not in the rate of absorption of palmitoyl glycerol, oxidative phosphorylation by liver or heart mitochondria, excretion of carbon dioxide and tissue distribution of radioactivity after gavage with rac-1(3)-[1-14C]palmitoyl glycerol.