Urticarial vasculitis secondary to paroxetine
Welsh, J.P.; Cusack, C.A.; Ko, C.
Journal of Drugs in Dermatology Jdd 5(10): 1012-1014
2006
ISSN/ISBN: 1545-9616 PMID: 17373154 Document Number: 15939
Paroxetine (Paxil) is a widely prescribed antidepressant of the selective serotonin reuptake inhibitor (SSRI) class for which multiple cutaneous adverse effects have been reported, including urticaria, ecchymoses, vasculitis, and pruritus. In contrast, fluoxetine (Prozac) is the only SSRI previously reported to cause urticarial vasculitis. Urticarial vasculitis is a chronic disorder marked by recurrent episodes of erythematous, indurated wheals that histologically manifest the features of leukocytoclastic vasculitis. This case represents the first reported incidence of paroxetine-induced urticarial vasculitis, and highlights the need to consider the entire SSRI class as s as a potential cause of the condition.
Document emailed within 1 workday
