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Carcinogenicity of nitrosotrialkylureas in Fischer 344 rats

Lijinsky, W.; Reuber, M.D.; Blackwell, B.N.

Journal of the National Cancer Institute 65(2): 451-453

1980

ISSN/ISBN: 0027-8874
PMID: 6931260
Document Number: 159339
Three nitrosotrialkylureas were administered to female F344 rats as approximately 1-mM solutions in drinking water. Nitrosotrimethylurea, given for 47 weeks, gave rise to astrocytomas of the brain and tumors of the forestomach; nitrosotriethylurea induced a high incidence of adenocarcinomas of the breast and uterus and tumors of the forestomach. Nitrosomethyldiethylurea induced almost exclusively a high incidence of both astrocytomas of the brain and tumors of the spinal cord.

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