Mechanism for exclusion of 5-fluorouracil from DNA
Ingraham, H.A.; Tseng, B.Y.; Goulian, M.
Cancer Research 40(4): 998-1001
1980
ISSN/ISBN: 0008-5472 PMID: 6101994 Document Number: 158331
5-Fluorodeoxyuridine 5'-triphosphate is hydrolyzed by the enzyme deoxyuridine triphosphate diphosphohydrolase (EC 3.6.1.23). Uracil-DNA glycosylase removes 5-fluorouracil (FUra) from FUra-containing DNA similar to its removal of uracil from uracil-containing DNA. The absence of FUra in DNA following exposure of cells to FUra can be explained by the activities of these two enzymes.
Document emailed within 1 workday
Related Documents
Roy, S. 1995: L'itinérance : forme exemplaire d'exclusion sociale ? - Homelessness : an exemplary form of social exclusion ? - La itinerancia : ¿ una forma ejemplar de exclusión social ? Revue Internationale d'Action Communautaire (Montreal) (74): 73-80Iba, T.; Kidokoro, A.; Fukunaga, M.; Sugiyama, K.; Fukunaga, T.; Aihara, N. 2003: Effect and mechanism of orally administered leucovorin/5-fluorouracil on colon cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 30(13): 2077-2081
Jiang, J.; Liu, J.; Zhu, J.; Yang, C.; Zhang, A. 2002: Mechanism of apoptotic effects induced by 5-fluorouracil on human liver carcinoma Bel7402 cell line Chinese Medical Journal 115(7): 968-971
Aschele, C.; Sobrero, A.; Faderan, M.A.; Bertino, J.R. 1992: Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules Cancer Research 52(7): 1855-1864
Tett, L.; Munn, P.; Blair, A.; Kay, H.; Martin, I.; Martin, J.; Ranson, S. 2001: Collaboration between schools and community education agencies in tackling social exclusion - Coopération entre les écoles et les services éducatifs communautaires dans la lutte contre l'exclusion sociale Research Papers in Education 16(1): 3-21
Li, J.; Wang, S.-X. 2016: Synergistic enhancement of the antitumor activity of 5-fluorouracil by bornyl acetate in SGC-7901 human gastric cancer cells and the determination of the underlying mechanism of action Journal of Buon: Official Journal of the Balkan Union of Oncology 21(1): 108-117
Luciano, A. 1993: Mal di scuola. Ragazze e ragazzi in cammino verso l'esclusione sociale - School ache. Boys and girls heading for social exclusion - Le mal de l'école. Filles et garçons en route vers l'exclusion sociale Quaderni di Sociologia 37(6): 26-36
Schumacher, K. 2000: Comparison of fluorouracil + folinic acid, fluorouracil + levamisole and fluorouracil + folinic acid + levamisole in Dukes' B and C colon cancer: NSABP Trial C-04 Strahlentherapie und Onkologie: Organ der Deutschen Rontgengesellschaft . 176(5): 239-240
Fujii, S.; Kitano, S.; Ikenaka, K.; Fukushima, M.; Nakamura, H.; Maehara, Y.; Shirasaka, T. 1980: Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil Gan 71(1): 100-106
Shirasaka, T.; Shimamoto, Y.; Kato, T.; Fukushima, M. 1998: Invention of a tumor-selective 5-fluorouracil derivative named S-1 by biochemical modulation of 5-fluorouracil Gan to Kagaku Ryoho. Cancer and ChemoTherapy 25(3): 371-384
Yamashita, K.; Mitani, K.; Morishita, Y.; Inoue, K. 1989: The concentration of 5-fluorouracil in blood and tissues of the patients with carcinoma of the cervix after administration of UFT and 5-fluorouracil Gan to Kagaku Ryoho. Cancer and ChemoTherapy 16(4 Part 1): 767-773
Iigo, M.; Kuretani, K.; Hoshi, A. 1981: Metabolic fate on 1-hexylcarbamoyl-5-fluorouracil and 5-fluorouracil in mice bearing ascites sarcoma 180 Journal of the National Cancer Institute 66(2): 345-349
El Sayed, Y.M.; Sadée, W. 1983: Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes Cancer Research 43(9): 4039-4044
Tamemasa, O.; Tezuka, M. 1983: Antitumor effect of 5-fluorouracil in combination with some additives which stimulate the formation of antineoplastic 5-fluorouracil nucleotides Gan 74(2): 285-290
Praud, J. 2001: French women and the liberal model of political citizenship: From exclusion to inclusion? - Les femmes françaises et le modèle libéral de citoyenneté politique : de l'exclusion à l'inclusion? Contemporary French Civilization 25(2): 250-270
Shaib, W.; Lee, V.; Saif, M.W. 2009: Bolus 5-Fluorouracil as an alternative modality to infusion 5-Fluorouracil in a patient with rectal cancer and capecitabine-induced cardiotoxicity In Vivo 23(5): 821-826
Yee, L.K.; Allegra, C.J.; Steinberg, S.M.; Grem, J.L. 1992: Decreased catabolism of fluorouracil in peripheral blood mononuclear cells during combination therapy with fluorouracil, leucovorin, and interferon alpha-2a Journal of the National Cancer Institute 84(23): 1820-1825
Toide, H.; Akiyoshi, H.; Minato, Y.; Okuda, H.; Fujii, S. 1977: Comparative studies on the metabolism of 2-(tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil Gan 68(5): 553-560
Menezes Pereira, S. 2002: Globalização, descentralização e exclusão social: grandes e novos desafios para a gestão escolar - Globalization, decentralisation and social exclusion: great and new challenges for the school management - Mondialisation, décentralisation et exclusion sociale : de nouveaux défis pour la gestion scolaire Linhas Criticas (14): 119-138
Kilty, K.M.; Vidal de Haymes, M. 2000: Racism, nativism, and exclusion : Public policy, immigration, and the Latino experience in the United States - Racisme, nativisme et exclusion : politique publique, immigration et expérience Latino aux Etats-Unis Journal of Poverty 4(1-2): 1-25