Nephrotic syndrome during captopril therapy
Rosendorff, C.; Milne, F.J.; Levy, H.; Ninin, D.T.; Lewin, J.R.
South African Medical Journal 58(4): 172-173
1980
ISSN/ISBN: 0256-9574 PMID: 6996153 Document Number: 158309
Captopril, an angiotensin-converting enzyme inhibitor, is being evaluated as an antihypertensive agent. We report on a patient who developed the nephrotic syndrome while on captopril 450 mg/d. Her urinary protein excretion was 5-7 g/24 h, plasma albumin concentration was 25 g/l, plasma cholesterol was 16,2 mmol/l, and she had oedema. Renal biopsy showed subepithelial deposits on the basement membrane.