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The transient appearance of degenerate antibody early in the course of the immune response

Kan, E.A.; Siskind, G.W.

Journal of Immunology 124(4): 1758-1762

1980

ISSN/ISBN: 0022-1767
PMID: 6154079
Document Number: 157715
The appearance of degenerate antibody-secreting cells early in the course of the immune response was demonstrated. Mice immunized with SRBC produced plaques detectable on TNP-SRBC. Early after antigen injection, antibody is apparently produced that can react with the immunizing antigen and with structurally unrelated antigenic determinants. The incidence of such degenerate antibody-secreting cells is maximal at 3 days after antigen injection and decreases thereafter. The degenerate antibody is probably of very low affinity for the immunizing antigen.

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