Therapeutic effectiveness of the generic preparation of meropenem (Mapenem) in the treatment of moderate to severe infection in children
Punpanich, W.; Srisarang, S.; Prachantasen, U.
Journal of the Medical Association of Thailand 95(7): 895-902
2012
ISSN/ISBN: 0125-2208 PMID: 22919984 Document Number: 15682
To compare treatment effectiveness and tolerability between generic meropenem (Mapenem, Siam Pharmaceutical) and the original formulation. A retrospective review using historical control of children hospitalized at Queen Sirikit National Institute of Child Health was conducted. The demographics, clinical, and treatment outcomes of 180 children receiving generic meropenem were compared with that of 180 children receiving original meropenem. Baseline demographics, clinical characteristics were comparable between both groups. The treatment outcomes on day 3, 7, and 14 of treatment were comparable between the two groups with overall improvement rates of 73.9% and 71.7% for generic and original meropenem, respectively (absolute difference: 2.2%, 95% CI: -6.9%, 11.4%). Both drugs were well tolerated, with only 1.6% of patients in each group who experienced adverse reactions. Mapenem exhibited comparable therapeutic effectiveness and tolerability with that of the brand-name formulation in the treatment of moderate to severe infections in a pediatric population.
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