Bromosulfan and indocyanine green test in liver-damaged rats
Skorka, G.; Bien, E.
Acta Biologica et Medica Germanica 39(2-3): 271-276
1980
ISSN/ISBN: 0001-5318 PMID: 7424346 Document Number: 156798
The susceptibility and valuation of bromsulfthalein (BSP) and indocyanine green (ICG) tests in liver-damaged rats were investigated. The removal of BSP from the blood after the administration of carbon tetrachloride (0.1 ml/kg) showed a delay after 2 wk, while the content of ICG was only slightly altered. Impaired uptake or transport mechanisms into liver cells and impaired metabolism or elimination processes can be indicated by these findings. After application of aminophenazone (340 mg/kg), which resulted in detectable histological liver lesions, an accelerated elimination of the 2 dyes from the blood was observed, which was significant for BSP and may be caused by an induction effect.