The use of levonorgestrel - IUD in the treatment of uterine myoma in Thai women
Jindabanjerd, K.; Taneepanichskul, S.
Journal of the Medical Association of Thailand 89(Suppl 4): S147-S151
2006
ISSN/ISBN: 0125-2208 PMID: 17726816 Document Number: 15655
This study was designed to evaluate the potential usefulness of the levonorgestrel-releasing intrauterine device (LNG - IUD ; Mirena) in treating women with uterine myomas. Prospective before-and-after (comparing) study. Department of Obstetrics and Gynecology King Chulalongkorn Memorial Hospital. Sixteen women with uterine myomas who intended to receive treatment with the LNG IUD. Clinical and ultrasound examinations were performed prior to and at 1, 3 and 6 months after the LNG IUD insertion. Myoma and Uterine volume, menstrual blood loss assessed with pictorial blood loss assessment charts and hematocrit. Use of the LNG IUD was associated with a statistically significant reduction in the total myoma volume, average uterine size and marked reduction in menstrual blood loss. After 6 months of use, the median total myoma volume decreased from 19.82 mL to 11.63 mL (p < 0.05), median pictorial blood loss assessment chart score declined from 89 to 3 (p < 0.05). Hematocrit level increased over 6 months of use. The most common side effects were bleeding disturbances (68.8%). No pregnancies occurred during the study. The LNG IUD was associated with a profound reduction in myoma and uterine volume. For women with myomas of this size, the LNG IUD provides effective medical treatment of bleeding.