The effect of growth hormone administration on human sleep: a dose-response study

Mendelson, W.B.; Slater, S.; Gold, P.; Gillin, J.C.; Mendelson, W.B; Slater, S; Gold, P; Gillin, J.C

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The effect of growth hormone administration on human sleep: a dose-response study

Mendelson, W.B.; Slater, S.; Gold, P.; Gillin, J.C.

Biological Psychiatry 15(4): 613-618

1980

ISSN/ISBN: 0006-3223

PMID: 7397291

Document Number: 156523

Human growth hormone and saline were administered for one night each to normal volunteers in a cross-over study. A dose of 2 units im given 15 min before bedtime had no effect on sleep EEG parameters. In contrast, 5 units resulted in a 19% decrease in slow-wave sleep (p < 0.01) and a 13% increase in REM sleep (p < 0.05). Neither doe, when given during daytime, affected tests of affect or serial learning.