Sensitivity of the causative agents of suppurative-inflammatory diseases to medical bacteriophages
Men'shikov, D.D.; Ianisker, G.I.; Savel'eva, G.F.; Bialik, I.F.; Maksimov, I.M.
Antibiotiki 25(5): 356-359
1980
ISSN/ISBN: 0003-5637 PMID: 6446257 Document Number: 156266
Sensitivity to therapeutic bacteriophages and antibiotics of 2063 cultures causing purulent inflammatory diseases was studied. Sensitivity of Staph. aureus to therapeutic bacteriophages was higher (88.5%) than that to benzylpenicillin (33.7%), ampicillin (64.3%), erythromycin (53.7%) and close to that to aminoglycosides, tetracycline, lincomycin and chloramphenicol. The number of Ps. aeruginosa strains sensitive to the phages amounted to 67.1%. E. coli and Proteus were sensitive to therapeutic bacteriophages in 32.4 and 29% of the cultures respectively. All of the streptococcal strains isolated from the patients were resistant to phages. A favourable clinical effect of phages was observed in 37 out of 80 patients. The results of the study showed the advisability of the wide use of bacteriophages in combined treatment of purulent inflammatory diseases.