The Wolf-Hirschhorn syndrome. I. Genetics
Lurie, I.W.; Lazjuk, G.I.; Ussova, Y.I.; Presman, E.B.; Gurevich, D.B.
Clinical Genetics 17(6): 375-384
1980
ISSN/ISBN: 0009-9163 PMID: 7398109 Document Number: 156236
Four new cases of the Wolf-Hirschhorn syndrome are presented, 2 of which were due to t(4;22)mat. Review of the literature (> 100 cases of the Wolf-Hirschhorn syndrome) showed that 13% of all the reported cases were not mutations but segregations of parental chromosomal aberrations, primarily translocations. Similar data were obtained previously for other deletions (5p-, 18p-, 18q-). Analysis of data on some new deletion syndromes (Hq-, 8p-, 9p-, 10p-, 11p-, 11q-) revealed that 14.5% were inherited cases. All human autosomal deletions apparently have virtually the same genetic pattern.