The Study of the Golgi Apparatus in Blood – Basic Science and Clinical Applications
Zeng, L.; Hu, Z.; Lu, W.; Tang, X.; Zhang, J.; Li, T.; Yang, B.
Clinical Laboratory 56(5-6): 231-243
2010
ISSN/ISBN: 1433-6510 PMID: 20575472 Document Number: 15619
The Golgi apparatus (GA) is a cytoplasmic organelle that is of great interest to all scientists for its key role in the biosynthesis, transporting and sorting of both lipids and proteins located at the intersection of the secretory and endocytic pathways. Recently, more and more evidence shows that changes in the Golgi apparatus play an important role in the clinical progression and pathological development of many diseases. In this review, we will summarize the alteration of the Golgi apparatus in blood cells and anti-Golgi complex antibodies in blood serum under different conditions and further clarify the contribution of the Golgi apparatus dysfunction to the course of these diseases and its pathophysiological basis, which will significantly improve our understanding and impact our ability to develop more effective therapies for these diseases.
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