Simultaneous studies of serum and urinary proteins for evaluation and diagnosis of glomerular damages in proteinuric patients
Chuang, C.Y.; Chen, W.Y.; Yen, T.S.; Hsieh, B.S.; Lee, C.S.; Luo, S.F.; Lin, K.T.; Chen, C.Y.
Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 13(4): 376-385
1980
ISSN/ISBN: 0253-2662 PMID: 7226987 Document Number: 156170
Simultaneous studies of serum and urinary proteins in 294 adult proteinuric patients are presented. These studies may provide valuable guides for clinical diagnosis. In the group of idiopathic nephrotic syndrome, hypoalbuminemia, hypogammaglobulinemia and hyper-.alpha.2-globulinemia were most marked. Urinary protein electrophoresis (PEP) showed a well-selective pattern with albumin and .beta.-globulin as the main constituents. In the other groups of proteinuric patients the hypoalbuminemia and hyper-.alpha.2 globulinemia were milder and urinary PEP generally showed a non-selective pattern. In the groups of acute glomerulonephritis and lupus nephropathy, C3 [complement component 3] generally decreased; polyclonal gammopathy was frequently encountered and .alpha.1-acid glycoprotein increased. In the cases of chronic glomerulonephritis and diabetic nephropathy the levels of .gamma.-globulin, C3 and .alpha.1-acid glycoprotein were usually within normal limits. Urinary protein selectivity index in this series of adult patients was not a useful diagnostic parameter.