Current trends in the use of combined serum and vaccine in tetanus prevention
Olivo, R.; Fabio, U.
Bollettino dell'Istituto Sieroterapico Milanese 59(5): 455-463
1980
ISSN/ISBN: 0021-2547 PMID: 7248074 Document Number: 155796
There is evidence that when plain tetanus toxoid is given at the same time as antitoxin, the response to the toxoid is inhibited. Good responses can be obtained when absorbed tetanus toxoid is used with non-human antitoxin, but there is evidence of an interval (10-15 days) between the end of passive immunization and the beginning of the active one. Using absorbed tetanus toxoid at the same time as human antitoxin there is complete absence of interference. Therefore simultaneous active and passive immunization (only using absorbed tetanus toxoid and human immunoglobulins) can be a practicable procedure in the treatment of persons liable to contract tetanus as a result of injury.