Effects of antileukotriene among asthmatic patients
Saenghirunvattana, S.
Journal of the Medical Association of Thailand 84(5): 719-722
2001
ISSN/ISBN: 0125-2208 PMID: 11560223 Document Number: 1554
Study objective: To determine the effect of antileukotriene (montelukast) 10 mg once daily for the treatment of mild to moderate asthma. Design: Open label, prospective. Patients: Thirty asthmatic patients gtoreq18 years of age with baseline FEV1 >60 per cent and ltoreq80 per cent of predicted values and evidence of reversible airway obstruction, as defined by an increase in FEV1 of gtoreq20 per cent. Interventions: Montelukast 10 mg once daily orally for 12 weeks, back up beta-2 agonist inhaler was available, Measurement and results: Spirometry was performed during the screening period, and every month after starting antileukotriene. Subjects recorded asthma-related symptoms and use of supplement beta-2 agonists daily on diary cards. Over 12 weeks of treatment, the FEV1 increased 10 per cent, 14 per cent and 19 per cent respectively, compared to the baseline (p<0.05). The physician and patients evaluation scores were quite good in the study. Conclusion: Oral montelukast once daily gave a favorable effect in management of mild to moderate asthmatic patients.
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