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Conditions favoring production and mechanism of action of macrophage pyrogen

Sorokin, A.V.; Agasarov, L.G.; Efremov, O.M.

Biulleten' Eksperimental'noi Biologii i Meditsiny 89(3): 278-281

1980

ISSN/ISBN: 0365-9615
PMID: 6893002
Document Number: 155371
Activation of mononuclear phagocytes by staphylococci in vitro results in the production of endogenous pyrogen. Macrophage pyrogen does not posses species pyrogenic specificity. Intracisternal injection increases pyrogen susceptibility more than 100-fold as compared to intravenous injection. Still more abrupt increase in pyrogen susceptibility was observed in the animals in the presence of elevated body cAMP concentration induced by theophylline preinjection.

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