Effect of dietary fat on X-ray-induced mammary cancer in Sprague-Dawley rats
Silverman, J.; Shellabarger, C.J.; Holtzman, S.; Stone, J.P.; Weisburger, J.H.
Journal of the National Cancer Institute 64(3): 631-634
1980
ISSN/ISBN: 0027-8874 PMID: 6928247 Document Number: 155051
We studied the effect of dietary fat levels on the induction of mammary cancer by 350 rads total-body X-radiation given to noninbred albino Sprague-Dawley rats at 50 days of age. Compared to rats on a low-fat (LF) diet (5% lard), rats on a high-fat (HF) diet (20% lard) from 30 days of age had more tumors, with a higher multiplicity of carcinomas per rat. LF-fed groups exhibited a longer median tumor latency period thatn did HF-fed groups. A similar trend toward more tumors with an earlier time of death was seen in rats given single iv doses of 50 mg 1-methyl-1-nitrosourea/kg and fed an HF diet as compared to an LF diet.