Interaction of the genes of progressive muscular dystrophy (PMD) and blood groups (ABO)
Milani-Comparetti, M.; Valentini, B.; Capriotti, M.; Dellantonio, R.; Donati, D.; Lucchetti, L.; Nataloni, P.
Bollettino della Societa Italiana di Biologia Sperimentale 56(6): 542-544
1980
ISSN/ISBN: 0037-8771 PMID: 7378187 Document Number: 154864
Verification of the hypothesis that the inheritance of the Progressive Muscular Dystrophies (PMD) may involve dispersed genes, throiugh the study of a sample of 105 patients revealed that 82% of the Duchenne type belong to blood group O, while 79% of the limb-girdle type belong to group A. The fact that the Duchenne gene is sex-linked while the ABO locus is on chromosome 9 confirms the "dispersed genes" hypothesis, with important implications for further research, for genetic counselin and possibly for prevention.