The proliferative T cell response to herpes simplex virus (HSV) antigen is restricted by self HLA-D
Berle, E.J.; Thorsby, E.
Clinical and Experimental Immunology 39(3): 668-675
1980
ISSN/ISBN: 0009-9104 PMID: 6247109 Document Number: 154743
T cells from sensitized individuals react with a proliferative response to herpes simplex virus antigen (HSV-Ag) in vitro, when antigen is presented together with autologous macrophages (Mø). We here report that this T-Mø co-operation is restricted by self HLA-D/DR molecules of the sensitized T cell donor. Furthermore, it is shown that the lack of co-operation between T cells and HLA-D/DR disparate macrophages, is due neither to suppression nor to generation of cytotoxic T cells in the allogeneic mixture.
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