Non-allergic drug exanthemas
Goerz, G.; Merk, H.
Fortschritte der Medizin 98(19): 726-730
1980
ISSN/ISBN: 0015-8178 PMID: 6156882 Document Number: 154320
Drug reactions similar to allergic reactions according to the differentiation by Coombs and Gell--type I to type V--can be triggered by drugs without the interaction of antibodies and lymphocytes. The immediate hypersensitivity reaction (type I) is imitated in three ways: 1. Histamine release from mast cells or basophiles by drugs without regines (IgE, IgG4), 2. complement activation by a drug via the classic or alternative pathway without reaction with an antibody. 2. intolerance reaction, that means a chronic urticaria triggered by an inhibitor of the prostaglandin synthesis (Aspirin, other analgesics, food additives and dyes). In contrast to the above reactions, non-immune mechanisms mimicking type II to type V reactions are of inferior clinical importance.