Non-Hodgkin lymphoma in developmental age (morphological analysis and prognostic factors based on the Kiel classification)
Dura, W.T.; Wichrzycka, E.; Woźniewicz, B.; Gładkowska-Dura, M.; Cieślak, H.
Patologia Polska 30(3): 329-360
1979
ISSN/ISBN: 0031-3114 PMID: 396512 Document Number: 153535
A retrospective reevaluation was made of 116 cases previously diagnosed as lymphocytosarcoma, lymphoblastosarcoma, reticulosarcoma or lymphoma malignum in leukemia vertens. The diagnostic criteria of the Kiel classification were used. In 18 of 116 cases, proliferation in the histiocytic line (mainly malignant histiocytosis) was excluded from the analysis. In a selected group of 96 cases of NHL in 50 cases (51%), lymphoblastic L.M. in 30 cases, including convoluted type L.M. in 16 children (16,8%), type U L.M. in 13 children (13,8%), and Burkitt type L.M. in 1 case (1.1%). Immunoblastic malignant sarcoma was present in 4 cases (4.4%), and centrocytic L.M. in 5 children (5.4%). Follicular (nodular) proliferation was noted in 6 cases of centroblastic L.M., i.e., 7.3% of the series. In all histologic types (except Burkitt's L.M.), evolution toward lymphoblastic leukemia was observed. In more than 80% of convoluted L.M. and U L.M., acute lymphoblastic leukemia was present before initiation of therapy or appeared within 6 mo. after diagnosis. Thymic tumor was observed clinically and post mortem, mostly in cases of lymphoblastic L.M. and convoluted and U L.M. A characteristic feature of centroblastic L.M. was its localization in the small intestine. In more than 70% of children admitted to treatment, anatomic advancement of the tumor was of the IVth degree (according to the Ann Arbor center). Long survival was observed in 8 cases, i.e., 8.5% of the material of NHL.