Clinical pharmacology of phlebotropic drugs
Cepeláková, H.; Petrlík, M.; Cepelák, V.; Roubal, Z.
Folia Haematologica 106(5-6): 714-723
1979
ISSN/ISBN: 0323-4347 PMID: 94865 Document Number: 153336
Methods used in clinical and clinical pharmacological assessments of phlebotropic drugs are outlined. The knowledge of the pharmacokinetics and metabolism of phlebotropic drugs in human organism is far from complete as yet. Of objective methods proving haemodynamic effects of phlebotropic drugs, the authors have the best experiences with the strain-gauge type occlusive plethysmography, which is capable of proving a reduction of the capillary filtration fraction even after a single administration of an active preparation to healthy volunteers. The control of the patient's subjective complaints by phlebotropic drugs is documented by statistically significant findings in double-blind clinical trials with a placebo.