Biotransformation of drugs during aging
Gillette, J.R.
Federation Proceedings 38(5): 1900-1909
1979
ISSN/ISBN: 0014-9446 PMID: 428574 Document Number: 153007
Although the biological half-lives of many drugs appear to be longer in the elderly than in the young, the reasons for these longer half-lives are seldom clear, because the pharmacokinetic data obtained in humans are seldom sufficient to make a proper pharmacokinetic analysis. In the present paper are outlined the kinds of data required, the reasons they are required, and the possible consequences resulting from misinterpretation of inadequate data.