Autologous bone marrow transplantation in patients with cancer
Gale, R.P.; Graze, P.R.; Wells, J.; Ho, W.; Hershko, C.; Lowenberg, B.; Feig, S.; Cline, M.J.
Experimental Hematology 7(Suppl 5): 351-359
1979
ISSN/ISBN: 0301-472X PMID: 400697 Document Number: 152781
Ten patients with non-leukemic neoplasms received intensive, marrow-lethal doses of drugs and radiation followed by rescue with autologous cryopreserved bone marrow (nine) or marrow from an identical twin as part of a phase 1-2 study. Nine patients had extensive disease that was unresponsive to conventional therapy. Marrow engraftment was documented in all evaluable cases and most patients had a substantial anti-tumor response. Three patients are alive from 4 to 10 months following transplantation without evidence of disease.
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