The efficacy of drugs and psychotherapy in the treatment of acute depressive episodes
Weissman, M.M.; Prusoff, B.A.; Dimascio, A.; Neu, C.; Goklaney, M.; Klerman, G.L.
American Journal of Psychiatry 136(4b): 555-558
1979
ISSN/ISBN: 0002-953X PMID: 371421 Document Number: 152673
The efficacy of tricyclic antidepressants and various psychotherapies, in comparison with one another or in combination, has not been fully established in randomized clinical trials. The authors present a randomized controlled trial comparing the combination of amitriptyline and short-term interpersonal psychotherapy, either treatment alone, and nonscheduled supportive psychotherapy in ambulatory patients with acute depression. They found that pharmacotherapy and psychotherapy alone were equally efficacious and better than nonscheduled treatment. The combination treatment of psychotherapy and pharmacotherapy was more effective than either treatment alone and delayed the onset of symptomatic failure.