Topical 5-fluorouracil in the treatment of intraepithelial neoplasia of the vagina
Ballon, S.C.; Roberts, J.A.; Lagasse, L.D.
Obstetrics and Gynecology 54(2): 163-166
1979
ISSN/ISBN: 0029-7844 PMID: 460749 Document Number: 150773
Twelve patients with vaginal intraepithelial neoplasia received topical therapy with 5% 5-fluorouracil cream. Six patients had carcinoma in situ, 5 had moderate dysplasia, and 1 had mild dysplasia. Five patients responded to 1 treatment course. Six patients required 2, and 1 patient required 3 courses of therapy to respond. Three patients developed recurrent vaginal intraepithelial neoplasia 11-16 months after therapy and were retreated with topical 5-fluorouracil. Vaginal irritation occurred in all patients but was limited to the duration of the treatment course.