Mathematical models of cancer and their use in risk assessment
Whittemore, A.S.
Journal of Environmental Pathology and Toxicology 3(1-2): 353-362
1979
ISSN/ISBN: 0146-4779 PMID: 547018 Document Number: 150135
Cancer risk assessment necessarily involves the use of mathematical models. Although risk estimates can be extremely sensitive to underlying assumptions in such models, the assumptions are frequently overlooked when a particular model is used. This paper presents four examples to illustrate how the alteration of assumptions can have a large effect on risk estimates. Ways of avoiding undue model dependence are discussed.