Spray formulation of silver and hyaluronic acid in the treatment of superficial cutaneous ulcers of different etiopathogenesis: analysis of fifty-four clinical cases
Gazzabin, L.; Bucalossi, M.; Mariani, F.; Serantoni, S.
Panminerva Medica 53(3): 185-191
2011
ISSN/ISBN: 1827-1898 PMID: 21775945 Document Number: 15001
The aim of this study was to assess a spray formulation containing colloidal silver and hyaluronic acid. Patients included in the study were divided in two separate groups: 30 patients had chronic wounds and 24 patients had superficial traumatic wounds. Applications were performed at intervals of 3-7 days, depending upon lesions characteristics. Subsequent improvements were evaluated at various intervals after enrollment. The lesion area and the rate of re-epithelialization were calculated, considering the time span and monitoring the patients for clinical signs of wound infection. Patients satisfaction and compliance were evaluated by a questionnaire aimed at assessing pain and ease of use of the device. Chronic lesions were healed at week 12, with a high rate of closure observed at 6 weeks (70%). Furthermore, traumatic wounds healed at six weeks, with a substantial percentage of closure (80%) at three weeks. A good control of microbial contamination was evident in all the treated wounds; in no case other antimicrobial medications were used. Finally, patients favorably expressed compliance with regard to the spray formulation and ease of use. This type of clinical approach seems to be a rational good choice to promote re-epithelialization of superficial cutaneous ulcers of different origins as well as control of bacterial infections.
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