Serum prolactin response to acute and chronic cimetidine administration in man
Cavallini, G.; Lo Cascio, V.; Angelini, G.; Bovo, P.; Galvanini, G.; Vaona, B.; Cominacini, L.; Scuro, L.A.
Acta Hepato-Gastroenterologica 26(6): 482-485
1979
ISSN/ISBN: 0300-970X PMID: 549431 Document Number: 148921
The effects of cimetidine administration on the serum prolactin (PRL) response was studied in 20 healthy volunteers and 46 duodenal ulcer patients. Cimetidine acute administration in 2 different doses (200 or 400 mg i.v.) induced a similar conspicuous rise of PRL while CB154 [2.alpha.-bromoergocriptine], a dopaminergic drug, inhibited the increase. No high PRL level was seen when the drug was administered orally in a single acute dose (800 mg), or in the chronic short-term treatment (1 g/day for 28 days) for duodenal ulcer. Cimetidine has no or very slight antidopaminergic activity. Serum PRL increase after the drug is probably due to the H2-receptor blocking. This effect is seen only with the bolus i.v. of cimetidine, but not during or after acute and chronic oral administration.