Serum Fetuin A Concentrations in Patients with Acute Pancreatitis
Beata Kuśnierz-Cabala; Gurda, A.-Duda; Józefa Panek; Fedak, D.; Dumnicka, P.; Solnica, B.; Kulig, J.
Clinical Laboratory 56(5-6): 191-195
2010
ISSN/ISBN: 1433-6510 PMID: 20575466 Document Number: 14872
Background: Acute pancreatitis (AP) is a mild and self-limiting disease in most patients, but necrotizing pancreatitis develops in up to 20 - 30 % of the cases. Early recognition of severe AP has been considered as a key determinant of successful therapy. The aim of this study was to evaluate the clinical value of fetuin A as the new predictor of complications and fatal outcome during acute pancreatitis (AP). Methods: The study included 40 patients with AP of diverse severity (28 mild, 12 severe), assessed during the early phase of AP (1st – 7th day of hospitalization). Fetuin A level was measured by ELISA kit (BioVendor). Results: Median serum fetuin A concentrations had a tendency to decrease during examination from 0,371 g/L at admission to 0,288 g/L on the 7th day of hospitalization. In each of 7 days of observation, correlation between the increase in fetuin A and the absolute number of RBC was found (R = 0,34: 1st day R = 0,35: 3rd day, p Conclusions: Fetuin A level monitoring is potentially a new marker for non-invasive and accurate prediction status for the hospitalization of patients with AP similar to other negative acute phase proteins like albumin.
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