A conductance decrease after application of GABA to crayfish muscle fibers

Dudel, J.

Journal de Physiologie 75(6): 597-600

1979


ISSN/ISBN: 0021-7948
PMID: 547060
Document Number: 148667
Relaxations after voltage steps of membrane current elicited by superfusion with low concentrations of GABA (up to 50 mumol/l) were measured. In many preparations, a conductance decrease due to GABA was observed. The response to GABA was shown to consist of two major components: the well known opening of synaptic chloride channels, and the closing of previously open channels, presumably permeable to K+ ions. The latter component could not be blocked by picrotoxin.

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