From ergot alkaloids to nicergoline/Chemical points of view
Bernardi, L.
Arzneimittel-Forschung 29(8a): 1204-1206
1979
ISSN/ISBN: 0004-4172 PMID: 540064 Document Number: 148511
The author reports the rationale of a line of research that has led to pharmacologically active ergoline derivatives from the more complex ergot alkaloids. Specific compounds showing oxytocic, alpha-adrenolytic and antiserotoninic activity were synthesized and the relationship between structure and activity discussed. Out of the compounds, 10-methoxy-1,6-dimethyl-ergoline-8 beta-methanol-(5-bromonicotinate) (nicergoline) was chosen as the most interesting product for a detailed further development.