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Tumor-specific immunity induced by somatic hybrids. II. Elicitation of enhanced immunity against the parent plasmacytoma

Kim, B.S.

Journal of Immunology 123(2): 739-744

1979

ISSN/ISBN: 0022-1767
PMID: 88483
Document Number: 148018
Hybrid cells derived from fusion of a BALB/c plasmacytoma (TEPC-15) and L cell populations were primarily responsible for the transfer of specific immunity based on the sensitivity of immune cells to anti-Thy 1.2 and complement. Mice that had established solid tumors were treated with 5 .times. 107 spleen cells to evaluate the therapeutic value of the hybrid-induced immune cells. Tumors in the mice that received immune cells gradually regressed over a 40-day period whereas tumors on the control mice continued to grow. A rearrangement of tumor-specific antigens on allogeneic hybrid cells may enhance their immunogenicity.

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