Osteomalacia due to unusual causes presenting in adults
Melick, R.A.; Larkins, R.G.; Greenberg, P.B.; Wark, J.D.
Australian and New Zealand Journal of Medicine 9(3): 253-257
1979
ISSN/ISBN: 0004-8291 PMID: 288391 Document Number: 146787
Severe osteomalacia due to causes other than malabsorption and, where renal function was impaired, disproportionate to the degree of renal failure, is described in 15 adults. Only one was younger than 46 years, the median age being 59 years. The diagnosis was not made for months in most patients. After investigation, the patients were grouped as follows: nutritional three cases, "renal" six cases, hypophosphataemia three cases, neurofibromatosis and primary hyperparathyroidism one each. The last patient was poorly nourished and had taken anticonvulsants and analgesics. Most patients responded well to treatment with calciferol. These cases indicate the need to be aware that osteomalacia may occur in previously healthy middle-aged or elderly subjects.