T- and B-lymphocytes in patients with chronic renal failure and in recipients of cadaveric allokidneys during the immediate posttransplant period
Dzerzhinskaia, I.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 87(2): 174-176
1979
ISSN/ISBN: 0365-9615 PMID: 369635 Document Number: 146572
Investigations of the thymus-dependent and thymus-independent lymphocytes populations of patients with chronic renal failure showed the activity of the T-lymphocytes system to be depressed in these cases. Both the lymphocyte populations took part in the rejection, but the degree of their participation differed. There was a low activation of T-lymphocytes and a high activation of B-lymphocytes in case of inflammatory processes, abscess, frunculosis, hematoma, etc., when stable doses of immunodepressants were used. The evidence of participation of T- and B-lymphocytes in the rejection opens new approaches to the diagnosis of different pathological conditions in the recipient's organism.