Volatile N-nitrosamines in the urine of normal donors and of bladder cancer patients
Kakizoe, T.; Wang, T.T.; Eng, V.W.; Furrer, R.; Dion, P.; Bruce, W.R.
Cancer Research 39(3): 829-832
1979
ISSN/ISBN: 0008-5472 PMID: 427771 Document Number: 145784
Volatile N-nitrosamines were detected in the urine of male volunteers with gas-liquid and high-pressure liquid chromatography interfaced to the thermal energy analyzer. Of 50 samples from normal males, 10 contained nitrosodimethylamine (0.02 to 0.10 micrograms/liter), 6 contained nitrosodiethylamine (0.02 to 3.10), 9 contained nitrosomorpholine (0.006 to 0.67), and none contained nitrosodibutylamine. Of 4 samples from bladder cancer patients, 2 contained nitrosodibutylamine (0.35 and 0.66). Cigarette smoking did not appear to be related to the pattern or amount of urinary volatile N-nitrosamines. The possibility that the N-nitrosamines arise from the diet or from endogenous production is considered.