Pharmacological & biochemical characterization of antiparkinson drugs in reserpinized mice
David, J.; Kaul, C.L.; Grewal, R.S.
Indian Journal of Experimental Biology 17(8): 760-764
1979
ISSN/ISBN: 0019-5189 PMID: 575644 Document Number: 145271
The effect of various clinically useful anti-parkinson drugs was examined on reserpine-induced catatonia and oxotremorine-induced tremors in mice. Amantadine, apomorphine, atropine, clonidine and L-dopa significantly reversed reserpine-induced catatonia, but no highly significant changes in brain dopamine and noradrenaline (norepinephrine) levels were seen with the 1st 4 drugs, at the time of peak pharmacological antagonism. Chlorpromazine, imipramine, nitroxazepine, morphine and sodium phenobarbital were ineffective in reversing reserpine-induced extrapyramidal symptoms. The anticholinergic agent atropine and chlorpromazine were the most potent in inhibiting oxotremorine-induced tremors.