Dapsone and severe hypoalbuminaemia
Young, S.; Marks, J.M.
Lancet 2(8148): 908-909
1979
ISSN/ISBN: 0140-6736 PMID: 91005 Document Number: 144686
Severe hypoalbuminaemia developed in two patients on long-term dapsone treatment for dermatitis herpetiformis. The patients had been treated with dapsone for 3 and 11 years before the syndrome developed and both recovered completely when dapsone was withdrawn. Albumin-turnover studies revealed a great increase in intravascular albumin catabolism and a modest decrease in synthesis.